Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma

Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma

<i>Purpose</i>: Pancreatic ductal adenocarcinoma (PDAC) has the lowest five-year survival rate of all cancers in the United States. Programmed death 1 receptor (PD-1)-programmed death ligand 1 (PD-L1) immune checkpoint inhibition has been unsuccessful in clinical trials. Myeloid-derived...

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Bibliographic Details
Main Authors: Loryn Holokai, Jayati Chakrabarti, Joanne Lundy, Daniel Croagh, Pritha Adhikary, Scott S. Richards, Chantal Woodson, Nina Steele, Robert Kuester, Aaron Scott, Mohammad Khreiss, Timothy Frankel, Juanita Merchant, Brendan J. Jenkins, Jiang Wang, Rachna T. Shroff, Syed A. Ahmad, Yana Zavros
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma (PDAC)
myeloid derived suppressor cells (MDSCs)
PD-L1
organoids
organoid/immune-cell co-culture
Online Access:https://www.mdpi.com/2072-6694/12/12/3816

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https://www.mdpi.com/2072-6694/12/12/3816

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