Elimination of macrophages reduces glutaraldehyde‐fixed porcine heart valve degeneration in mice subdermal model

Abstract Glutaraldehyde‐fixed porcine heart valve (GPHV) calcify and deteriorate over time. The aim of this study was to explore the roles macrophages play in mediating calcification and degeneration of the valve's connective tissue matrix. GPHV were implanted subcutaneously in the abdomens of...

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Bibliographic Details
Main Authors: Zongtao Liu, Yixuan Wang, Fei Xie, Xing Liu, Fei Li, Nianguo Dong
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Pharmacology Research & Perspectives
Subjects:
Online Access:https://doi.org/10.1002/prp2.716