p38 MAPK Facilitates Crosstalk Between Endoplasmic Reticulum Stress and IL-6 Release in the Intervertebral Disc

p38 MAPK Facilitates Crosstalk Between Endoplasmic Reticulum Stress and IL-6 Release in the Intervertebral Disc

Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (...

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Bibliographic Details
Main Authors: Olga Krupkova, Aleksandra Sadowska, Takuya Kameda, Wolfgang Hitzl, Oliver Nic Hausmann, Juergen Klasen, Karin Wuertz-Kozak
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
intervertebral disc
inflammation
endoplasmic reticulum stress
p38 MAPK
CHOP
GADD153
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01706/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01706/full

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