UHPLC-QQQ-MS/MS assay for the quantification of dianthrones as potential toxic markers of Polygonum multiflorum Thunb: applications for the standardization of traditional Chinese medicines (TCMs) with endogenous toxicity

UHPLC-QQQ-MS/MS assay for the quantification of dianthrones as potential toxic markers of Polygonum multiflorum Thunb: applications for the standardization of traditional Chinese medicines (TCMs) with endogenous toxicity

Abstract Background The raw and processed roots of Polygonum multiflorum Thunb (PM) are commonly used in clinical practice to treat diverse diseases; however, reports of hepatotoxicity induced by Polygoni Multiflori Radix (PMR) and Polygoni Multiflori Radix Praeparata (PMRP) have emerged worldwide....

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Bibliographic Details
Main Authors: Jian-Bo Yang, Yun-Fei Song, Yue Liu, Hui-Yu Gao, Qi Wang, Ying Wang, Xian-Long Cheng, Tian-Tian Zuo, Xiao-Wen Hu, Feng Wei, Hong-Tao Jin, Shu-Ting Wang, Shuang-Cheng Ma
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Chinese Medicine
Subjects:
Polygonum multiflorum Thunb
Dianthrones
Endogenous toxic TCMs
Toxic markers
HepaRG cells
Online Access:https://doi.org/10.1186/s13020-021-00463-w

Internet

https://doi.org/10.1186/s13020-021-00463-w

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