A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions

Genetically-engineered mouse models (GEMMs) lacking diseased-associated gene(s) globally or in a tissue-specific manner represent an attractive tool with which to assess the efficacy and toxicity of targeted pharmacological inhibitors. <i>Stat3</i> and <i>Stat5a/b</i> transcr...

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Bibliographic Details
Main Authors: Herwig P. Moll, Julian Mohrherr, Leander Blaas, Monica Musteanu, Patricia Stiedl, Beatrice Grabner, Katalin Zboray, Margit König, Dagmar Stoiber, Thomas Rülicke, Sabine Strehl, Robert Eferl, Emilio Casanova
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
bacterial artificial chromosome
recombineering
Cre/loxP
gene targeting
embryonic stem cells
liver steatosis
Online Access:https://www.mdpi.com/2072-6694/11/9/1226

Internet

https://www.mdpi.com/2072-6694/11/9/1226

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