Plasticity of the 340-Loop in Influenza Neuraminidase Offers New Insight for Antiviral Drug Development

Plasticity of the 340-Loop in Influenza Neuraminidase Offers New Insight for Antiviral Drug Development

The recently discovered 340-cavity in influenza neuraminidase (NA) N6 and N7 subtypes has introduced new possibilities for rational structure-based drug design. However, the plasticity of the 340-loop (residues 342–347) and the role of the 340-loop in NA activity and substrate binding have not been...

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Bibliographic Details
Main Authors: Nanyu Han, Justin Tze Yang Ng, Yanpeng Li, Yuguang Mu, Zunxi Huang
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
influenza
neuraminidase
340-cavity
molecular dynamics simulations
Online Access:https://www.mdpi.com/1422-0067/21/16/5655

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https://www.mdpi.com/1422-0067/21/16/5655

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