THE TRAFFICKING OF THE WATER CHANNEL AQUAPORIN-2 IN RENAL PRINCIPAL CELLS – A POTENTIAL TARGET FOR PHARMACOLOGICAL INTERVENTION IN CARDIOVASCULAR DISEASES

THE TRAFFICKING OF THE WATER CHANNEL AQUAPORIN-2 IN RENAL PRINCIPAL CELLS – A POTENTIAL TARGET FOR PHARMACOLOGICAL INTERVENTION IN CARDIOVASCULAR DISEASES

Arginine-vasopressin (AVP) stimulates the redistribution of water channels, aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells. By this AVP directs 10 % of the water reabsorption from the 170 L of primary urine that the human kidneys prod...

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Bibliographic Details
Main Authors: Tanja eVukicevic, Maike eSchulz, Dörte eFaust, Enno eKlussmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Pharmacology
Subjects:
Heart Failure
cAMP
AKAP
AVP
PKA
SIADH
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00023/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00023/full

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