BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer

BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer

BRD4 belongs to the bromodomain and extraterminal (BET) family of chromatin reader proteins that bind acetylated histones and regulate gene expression. Pharmacological inhibition of BRD4 by BET inhibitors (BETi) has indicated antitumor activity against multiple cancer types. We show that BRD4 is ess...

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Bibliographic Details
Main Authors: Xiangyi Li, GuemHee Baek, Susmita G. Ramanand, Adam Sharp, Yunpeng Gao, Wei Yuan, Jon Welti, Daniel N. Rodrigues, David Dolling, Ines Figueiredo, Semini Sumanasuriya, Mateus Crespo, Adam Aslam, Rui Li, Yi Yin, Bipasha Mukherjee, Mohammed Kanchwala, Ashley M. Hughes, Wendy S. Halsey, Cheng-Ming Chiang, Chao Xing, Ganesh V. Raj, Sandeep Burma, Johann de Bono, Ram S. Mani
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
BRD4
BRD2
DNA repair
non-homologous end joining
NHEJ
gene fusion
genomic rearrangements
TMPRSS2-ERG
prostate cancer
CRPC
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319150

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http://www.sciencedirect.com/science/article/pii/S2211124717319150

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