Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway

Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway

Inflammatory Bowel Disease (IBD) is an autoimmune ailment of the gastrointestinal (GI) tract, which is characterized by enhanced activation of proinflammatory cytokines. It is suggested that the sigma-1 receptor (σ1R) confers anti-inflammatory effects. As the exact pathogenesis of IBD is still unkno...

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Bibliographic Details
Main Authors: Nikoletta Almási, Szilvia Török, Szabolcs Dvorácskó, Csaba Tömböly, Ákos Csonka, Zoltán Baráth, Zsolt Murlasits, Zsuzsanna Valkusz, Anikó Pósa, Csaba Varga, Krisztina Kupai
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
sigma receptor
fluvoxamine
inflammation
UCHL-1
Online Access:https://www.mdpi.com/1422-0067/21/11/4046

Internet

https://www.mdpi.com/1422-0067/21/11/4046

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