Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery.

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery.

Amongst the Plasmodium species in humans, only P. vivax and P. ovale produce latent hepatic stages called hypnozoites, which are responsible for malaria episodes long after a mosquito bite. Relapses contribute to increased morbidity, and complicate malaria elimination programs. A single drug effecti...

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Bibliographic Details
Main Authors: Laurent Dembele, Audrey Gego, Anne-Marie Zeeman, Jean-François Franetich, Olivier Silvie, Armelle Rametti, Roger Le Grand, Nathalie Dereuddre-Bosquet, Robert Sauerwein, Geert-Jan van Gemert, Jean-Christophe Vaillant, Alan W Thomas, Georges Snounou, Clemens H M Kocken, Dominique Mazier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3069045?pdf=render

Internet

http://europepmc.org/articles/PMC3069045?pdf=render

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