Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain

Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain

Cathepsin D deficiency is a fatal neurodegenerative disease characterized by extreme loss of neurons and myelin. Our previous studies have demonstrated that structural and functional alterations in synapses are central to the disease pathogenesis. Therefore, we took a systematic approach to examine...

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Bibliographic Details
Main Authors: Sabine Koch, Enzo Scifo, Anne Rokka, Pascal Trippner, Maria Lindfors, Reeta Korhonen, Garry L. Corthals, Ismo Virtanen, Maciej Lalowski, Jaana Tyynelä
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Neurobiology of Disease
Subjects:
Cathepsin D deficiency
iTRAQ
Cytoskeleton
Focal adhesions
Integrin assembly
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003324

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http://www.sciencedirect.com/science/article/pii/S0969996112003324

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