lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence

lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence

Long noncoding RNAs (lncRNAs) undergo extensive alternative splicing, but little is known about isoform functions. A prior investigation of lncRNA RP11-369C8.1 reported that its splice variant TRMP suppressed p27 translation through PTBP1. Here we characterize a second major splice variant, TRMP-S (...

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Bibliographic Details
Main Authors: Tian Shuai, Muhammad Riaz Khan, Xu Dong Zhang, Jingmin Li, Rick Francis Thorne, Mian Wu, Fengmin Shao
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
alternative splicing
FUBP3
lncRNA isoform
p53
p21
RP11-369C8.1
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000986

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http://www.sciencedirect.com/science/article/pii/S2162253121000986

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