Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity

Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity

Accumulating data have indicated that citrus polymethoxyflavones (PMFs) have the ability to affect brain function. In the present study, we showed that 3,5,6,7,8,3′,4′-heptamethoxy- flavone (HMF) given intraperitoneally to mice was immediately detected in the brain and that the permeability of the b...

Full description

Bibliographic Details
Main Authors: Satoshi Okuyama, Kohei Miyazaki, Rie Yamada, Yoshiaki Amakura, Morio Yoshimura, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukawa
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:International Journal of Molecular Sciences
Subjects:
polymethoxyflavone
heptamethoxyflavone
nobiletin
tangeretin
natsudaidain
blood-brain-barrier
locomotive hyperactivity
ERK1/2
MK-801
Online Access:http://www.mdpi.com/1422-0067/18/3/489

Internet

http://www.mdpi.com/1422-0067/18/3/489

Similar Items