Varicella-Zoster Virus Infectious Cycle: ER Stress, Autophagic Flux, and Amphisome-Mediated Trafficking

Varicella-Zoster Virus Infectious Cycle: ER Stress, Autophagic Flux, and Amphisome-Mediated Trafficking

Varicella-zoster virus (VZV) induces abundant autophagy. Of the nine human herpesviruses, the VZV genome is the smallest (~124 kbp), lacking any known inhibitors of autophagy, such as the herpes simplex virus ICP34.5 neurovirulence gene. Therefore, this review assesses the evidence for VZV-induced c...

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Bibliographic Details
Main Authors: Charles Grose, Erin M. Buckingham, John E. Carpenter, Jeremy P. Kunkel
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Pathogens
Subjects:
autophagy
varicella-zoster virus
cytomegalovirus
herpes simplex virus
glycoproteins
unfolded protein response
ER-associated degradation
XBP1
xenophagy
Online Access:http://www.mdpi.com/2076-0817/5/4/67

Internet

http://www.mdpi.com/2076-0817/5/4/67

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