Impaired hepatic amyloid-beta degradation in Alzheimer's disease.

Extensive research strongly suggests that amyloid beta (Aβ) aggregates in the brain have a central role in Alzheimer's disease (AD) pathogenesis. Pathological Aβ deposition is likely due to an altered balance between overproduction and elimination. Rodent studies have suggested that the liver h...

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Bibliographic Details
Main Authors: Chera L Maarouf, Jessica E Walker, Lucia I Sue, Brittany N Dugger, Thomas G Beach, Geidy E Serrano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6128628?pdf=render