Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?

Abstract Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions.

Bibliographic Details
Main Authors: Maria Dimou, Aikaterini Bitsani, Maria Roumelioti, Aglaia Dimitrakopoulou, Theodore Iliakis, Vasileios Pardalis, Ioannis Grafakos, Sotiria Kalyva, Athanasios Markopoulos, Marie‐Christine Kyrtsonis, Panayiotis Panayiotidis
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Clinical Case Reports
Subjects:
Online Access:https://doi.org/10.1002/ccr3.4002