A systems view of the differences between APOE ε4 carriers and non-carriers in Alzheimer’s disease

A systems view of the differences between APOE ε4 carriers and non-carriers in Alzheimer’s disease

APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and accounts for 50-65% of late-onset AD. Late-onset AD patients carrying or not carrying APOE ε4 manifest many clinico-pathological distinctions. Thus, we applied a weighted gene co-expression network analysis to i...

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Bibliographic Details
Main Authors: Shan Jiang, Ling Tang, Na Zhao, Wanling Yang, Yu Qiu, Hong-zhuan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer's disease
APOE E4 allele
weighted gene co-expression network analysis
APOE E4 carriers and non-carriers
hub gene cluster
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00171/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00171/full

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