Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the Toll-Like Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the Toll-Like Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. The activation of the toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-κB (TLR4/MyD88/NF-κB) pathway contributes to the development and progression of HCC. The ubiquitin–proteas...

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Bibliographic Details
Main Authors: Shan Gao, Tianxiang Chen, Lijie Li, Xin Liu, Yang Liu, Junjun Zhao, Qiliang Lu, Zhi Zeng, Qiuran Xu, Dongsheng Huang, Kangsheng Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hepatocellular carcinoma
deubiquitinase
ubiquitin-specific protease 13
toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-κB pathway
tumor progression
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.587389/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.587389/full

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