c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.

c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.

Skeletal abnormalities including osteoporosis and osteopenia occur frequently in both pediatric and adult neurofibromatosis type 1 (NF1) patients. NF1 (Nf1) haploinsufficient osteoclasts and osteoclast progenitors derived from both NF1 patients and Nf1(+/-) mice exhibit increased differentiation, mi...

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Bibliographic Details
Main Authors: Yongzheng He, Steven D Rhodes, Shi Chen, Xiaohua Wu, Jin Yuan, Xianlin Yang, Li Jiang, Xianqi Li, Naoyuki Takahashi, Mingjiang Xu, Khalid S Mohammad, Theresa A Guise, Feng-Chun Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3492362?pdf=render

Internet

http://europepmc.org/articles/PMC3492362?pdf=render

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