Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment

Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment

Abstract Introduction In a cancer-free environment in the adult, the skeleton continuously undergoes remodeling. Bone-resorbing osteoclasts excavate erosion cavities, and bone-depositing osteoblasts synthesize osteoid matrix that forms new bone, with no net bone gain or loss. When metastatic breast...

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Bibliographic Details
Main Authors: Alexus D. Kolb, Alison B. Shupp, Dimpi Mukhopadhyay, Frank C. Marini, Karen M. Bussard
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Breast Cancer Research
Subjects:
Osteoblast
Breast cancer cell
Bone
Metastasis
Proliferation
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s13058-019-1117-0

Internet

http://link.springer.com/article/10.1186/s13058-019-1117-0

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