Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD

Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD

TEAD (TEA/ATTS domain) transcription factors are the most distal effectors of the Hippo pathway. YAP (Yes-associated protein) is a coactivator protein which, upon binding to TEAD proteins, stimulates their transcriptional activity. Since the Hippo pathway is deregulated in various cancers, designing...

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Bibliographic Details
Main Authors: Yannick Mesrouze, Fedir Bokhovchuk, Marco Meyerhofer, Patrizia Fontana, Catherine Zimmermann, Typhaine Martin, Clara Delaunay, Dirk Erdmann, Tobias Schmelzle, Patrick Chène
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
protein-protein interaction
intrinsically disordered protein
molecular recognitiom
Online Access:https://elifesciences.org/articles/25068

Internet

https://elifesciences.org/articles/25068

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