Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer

Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer

The FOXM1 transcription factor is an oncoprotein and a top biomarker of poor prognosis in human cancer. Overexpression and activation of FOXM1 is frequent in high-grade serous carcinoma (HGSC), the most common and lethal form of human ovarian cancer, and is linked to copy number gains at chromosome...

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Bibliographic Details
Main Authors: Carter J Barger, Linda Chee, Mustafa Albahrani, Catalina Munoz-Trujillo, Lidia Boghean, Connor Branick, Kunle Odunsi, Ronny Drapkin, Lee Zou, Adam R Karpf
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
FOXM1
RHNO1
ovarian cancer
PARP inhibitors
bidirectional genes
DNA repair
Online Access:https://elifesciences.org/articles/55070

Internet

https://elifesciences.org/articles/55070

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