Proerythroblast Cells of Diamond-Blackfan Anemia Patients With RPS19 and CECR1 Mutations Have Similar Transcriptomic Signature

Proerythroblast Cells of Diamond-Blackfan Anemia Patients With RPS19 and CECR1 Mutations Have Similar Transcriptomic Signature

Diamond Blackfan Anemia (DBA) is an inherited bone marrow (BM) failure syndrome, characterized by a paucity of erythroid differentiation. DBA is mainly caused by the mutations in ribosomal protein genes, hence classified as ribosomopathy. However, in approximately 30% of patients, the molecular etio...

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Bibliographic Details
Main Authors: Beren Karaosmanoglu, M. Alper Kursunel, Duygu Uckan Cetinkaya, Fatma Gumruk, Gunes Esendagli, Sule Unal, Ekim Z. Taskiran
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
Diamond Blackfan Anemia
ribosomopathy
proerythroblast
RPS19
CECR1
transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.679919/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.679919/full

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