Higher Arc Nucleus-to-Cytoplasm Ratio during Sleep in the Superficial Layers of the Mouse Cortex

The activity-regulated cytoskeleton associated protein Arc is strongly and quickly upregulated by neuronal activity, synaptic potentiation and learning. Arc entry in the synapse is followed by the endocytosis of glutamatergic AMPA receptors (AMPARs), and its nuclear accumulation has been shown in vi...

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Bibliographic Details
Main Authors: Sakiko Honjoh, Luisa de Vivo, Hiroyuki Okuno, Haruhiko Bito, Giulio Tononi, Chiara Cirelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Neural Circuits
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Online Access:http://journal.frontiersin.org/article/10.3389/fncir.2017.00060/full