Effect of Electro-Acupuncture at ST36 and SP6 on the cAMP -CREB Pathway and mRNA Expression Profile in the Brainstem of Morphine Tolerant Mice

Effect of Electro-Acupuncture at ST36 and SP6 on the cAMP -CREB Pathway and mRNA Expression Profile in the Brainstem of Morphine Tolerant Mice

Undoubtedly, opioid drugs have been the most popular treatment for refractory pain since found, such as morphine. However, tolerance to the analgesic effects caused by repeated use is inevitable, which greatly limits the clinical application of these drugs. Nowadays, it has become the focus of the w...

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Bibliographic Details
Main Authors: Qisheng Wang, Fenfen Qin, Hui Wang, Huanya Yang, Qingyang Liu, Zhonghao Li, Yongwei Jiang, Shengfeng Lu, Qian Wang, Zhigang Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Neuroscience
Subjects:
electro-acupuncture
cAMP
PKA/ERK
CREB
morphine-induced analgesic tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.698967/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.698967/full

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