Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: evidence for functional effects of synonymous polymorphisms

<p>Abstract</p> <p>Background</p> <p>Complementary single-nucleotide polymorphisms (SNPs) may not be distributed equally between two DNA strands if the strands are functionally distinct, such as in transcribed genes. In introns, an excess of A↔G over the complementary C...

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Bibliographic Details
Main Authors: Majewski Jacek, Guo Fan, Lawrence Steve G, Qu Hui-Qi, Polychronakos Constantin
Format: Article
Language:English
Published: BMC 2006-08-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/7/213