CpG Methylation Profiles of HIV-1 Pro-Viral DNA in Individuals on ART

CpG Methylation Profiles of HIV-1 Pro-Viral DNA in Individuals on ART

The latent HIV-1 reservoir is comprised of stably integrated and intact proviruses with limited to no viral transcription. It has been proposed that latent infection may be maintained by methylation of pro-viral DNA. Here, for the first time, we investigate the cytosine methylation of a replication...

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Bibliographic Details
Main Authors: Valerie F. Boltz, Cristina Ceriani, Jason W. Rausch, Wei Shao, Michael J. Bale, Brandon F. Keele, Rebecca Hoh, Jeffrey M. Milush, Steve G. Deeks, Frank Maldarelli, Mary F. Kearney, John M. Coffin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
CpG dinucleotide methylation
HIV latency
single genome sequencing
RNA expression
transcriptional silencing
Online Access:https://www.mdpi.com/1999-4915/13/5/799

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https://www.mdpi.com/1999-4915/13/5/799

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