PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.

PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.

Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is usually associated with mutagenesis. In Saccharomyces cerevisiae a key event in TLS is the monoubiquitination of PCNA, which enables re...

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Bibliographic Details
Main Authors: Ayal Hendel, Peter H L Krijger, Noam Diamant, Zohar Goren, Petra Langerak, Jungmin Kim, Thomas Reissner, Kyoo-young Lee, Nicholas E Geacintov, Thomas Carell, Kyungjae Myung, Satoshi Tateishi, Alan D'Andrea, Heinz Jacobs, Zvi Livneh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3169526?pdf=render

Internet

http://europepmc.org/articles/PMC3169526?pdf=render

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