Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase

Alzheimer´s disease (AD) is a devastating neurodegenerative disease of the elderly population. Genetic evidence strongly suggests that aberrant generation and/or clearance of the neurotoxic amyloid-β peptide (Aβ) is triggering the disease. Aβ is generated from the amyloid precursor protein (APP) by...

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Bibliographic Details
Main Authors: Harald Steiner, Akio Fukumori, Shinji Tagami, Masayasu Okochi
Format: Article
Language:English
Published: Shared Science Publishers OG 2018-10-01
Series:Cell Stress
Subjects:
Alzheimer's disease
amyloid β-peptide
presenilin
γ-secretase
Online Access:http://www.cell-stress.com/researcharticles/making-the-final-cut-pathogenic-amyloid-%CE%B2-peptide-generation-by-%CE%B3-secretase/

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http://www.cell-stress.com/researcharticles/making-the-final-cut-pathogenic-amyloid-%CE%B2-peptide-generation-by-%CE%B3-secretase/

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