Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes.

Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes.

MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active MYD88 mutations have recently been reported in lymphoid malignancies, but has not been described in MDS. To characterize MYD88 in MDS, we sequenced the coding region of the MYD88 gene in 40 MDS patients. No...

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Bibliographic Details
Main Authors: Sophie Dimicoli, Yue Wei, Carlos Bueso-Ramos, Hui Yang, Courtney Dinardo, Yu Jia, Hong Zheng, Zhihong Fang, Martin Nguyen, Sherry Pierce, Rui Chen, Hui Wang, Chenghua Wu, Guillermo Garcia-Manero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3744562?pdf=render

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http://europepmc.org/articles/PMC3744562?pdf=render

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