Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats

Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats

The liver injury induced by Polygonum multiflorum (PM) used for clinical treatment has recently received widespread attention. This study aimed to determine the hepatotoxicity of PM through pharmacokinetics studies. The extract of PM was separated to isolate the anthraquinone fraction, the tannin an...

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Bibliographic Details
Main Authors: Miao Zhang, Longfei Lin, Hongmei Lin, Changhai Qu, Lei Yan, Jian Ni
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
Polygonum multiflorum
hepatotoxicity
pharmacokinetics
LC-MS/MS
different extraction parts
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00505/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00505/full

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