Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery

Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery

Ascorbic acid bound to KMUP-1 and sildenafil were examined for their antioxidant effects on vascular endothelium growth factor (VEGF) and endothelium nitric oxide synthase (eNOS) in hypoxic pulmonary artery (PA). Inhaled KMUP-1 and oral sildenafil released NO from eNOS. The effect of buffered l-asco...

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Bibliographic Details
Main Authors: Jiunn-Ren Wu, Li-Pin Kao, Bin-Nan Wu, Zen-Kong Dai, Yi-Ya Wang, Chee-Yin Chai, Ing-Jun Chen
Format: Article
Language:English
Published: Wiley 2015-05-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
Endothelium nitric oxide synthase
Hypoxia
Pulmonary arterial hypertension
Rho kinase II
Vascular endothelium growth factor
Online Access:http://www.sciencedirect.com/science/article/pii/S1607551X15000431

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http://www.sciencedirect.com/science/article/pii/S1607551X15000431

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