Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study.

Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study.

Imputation has been widely used in genome-wide association studies (GWAS) to infer genotypes of un-genotyped variants based on the linkage disequilibrium in external reference panels such as the HapMap and 1000 Genomes. However, imputation has only rarely been performed based on family relationships...

Full description

Bibliographic Details
Main Authors: Ming-Huei Chen, Jie Huang, Wei-Min Chen, Martin G Larson, Caroline S Fox, Ramachandran S Vasan, Sudha Seshadri, Christopher J O'Donnell, Qiong Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3524237?pdf=render

Internet

http://europepmc.org/articles/PMC3524237?pdf=render

Similar Items