Disrupting Inflammation-Associated CXCL8-CXCR1 Signaling Inhibits Tumorigenicity Initiated by Sporadic- and Colitis-Colon Cancer Stem Cells

Disrupting Inflammation-Associated CXCL8-CXCR1 Signaling Inhibits Tumorigenicity Initiated by Sporadic- and Colitis-Colon Cancer Stem Cells

Dysfunctional inflammatory pathways are associated with an increased risk of cancer, including colorectal cancer. We have previously identified and enriched for a self-renewing, colon cancer stem cell (CCSC) subpopulation in primary sporadic colorectal cancers (CRC) and a related subpopulation in ul...

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Bibliographic Details
Main Authors: Robert C. Fisher, Kishan Bellamkonda, L. Alex Molina, Shao Xiang, David Liska, Samaneh K. Sarvestani, Susmita Chakrabarti, Annamarie Berg, Marda L. Jorgensen, Denise Hatala, Sugong Chen, Alexandra Aiello, Henry D. Appelman, Edward W. Scott, Emina H. Huang
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558618305931

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http://www.sciencedirect.com/science/article/pii/S1476558618305931

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