ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice

ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice

OBJECTIVES: The present study aimed to investigate cardiovascular autonomic modulation and angiotensin II (Ang II) activity in diabetic mice that were genetically engineered to harbor two or three copies of the angiotensin-converting enzyme gene. METHODS: Diabetic and non-diabetic mice harboring 2...

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Bibliographic Details
Main Authors: Oscar Albuquerque de Moraes, Karin Flues, Kátia Bilhar Scapini, Cristiano Mostarda, Fabiana de Sant’Anna Evangelista, Bruno Rodrigues, Daniela Ravizzoni Dartora, Patricia Fiorino, Kátia De Angelis, Maria Cláudia Irigoyen
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2018-08-01
Series:Clinics
Subjects:
Renin-angiotensin System
Autonomic Nervous System
Renal Angiotensin System
Mice
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100245&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100245&lng=en&tlng=en

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