Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia.

Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia.

We have recently established a protocol to grow wildtype human oral mucosa organoids. These three-dimensional structures can be maintained in culture long-term, do not require immortalization, and recapitulate the multilayered composition of the epithelial lining of the oral mucosa. Here, we validat...

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Bibliographic Details
Main Authors: E Driehuis, N Oosterom, S G Heil, I B Muller, M Lin, S Kolders, G Jansen, R de Jonge, R Pieters, H Clevers, M M van den Heuvel-Eibrink
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0231588

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https://doi.org/10.1371/journal.pone.0231588

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