Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties

Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties

Potassium channel openers (KCOs) have been shown to play a role in cytoprotection through the activation of mitochondrial potassium channels. Recently, in several reports, a number of data has been described as off-target actions for KCOs. In the present study, we investigated the effects of BKCa ch...

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Bibliographic Details
Main Authors: Bartłomiej Augustynek, Piotr Koprowski, Daria Rotko, Wolfram S. Kunz, Adam Szewczyk, Bogusz Kulawiak
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
potassium channel openers
mitoBKCa channel
neuronal cells
cytotoxicity
mitochondria
Online Access:http://www.mdpi.com/1422-0067/19/2/353

Internet

http://www.mdpi.com/1422-0067/19/2/353

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