Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels.

Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels.

To study the individual functions of hyaluronan interacting proteins in prostate cancer (PCa) motility through connective tissues, we developed a novel three-dimensional (3D) hyaluronic acid (HA) hydrogel assay that provides a flexible, quantifiable, and physiologically relevant alternative to curre...

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Bibliographic Details
Main Authors: Lisa A Gurski, Xian Xu, Lyana N Labrada, Ngoc T Nguyen, Longxi Xiao, Kenneth L van Golen, Xinqiao Jia, Mary C Farach-Carson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3500332?pdf=render

Internet

http://europepmc.org/articles/PMC3500332?pdf=render

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