Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

Summary: Ion channel modulation by general anesthetics is a vital pharmacological process with implications for receptor biophysics and drug development. Functional studies have implicated conserved sites of both potentiation and inhibition in pentameric ligand-gated ion channels, but a detailed str...

Full description

Bibliographic Details
Main Authors: Zaineb Fourati, Rebecca J. Howard, Stephanie A. Heusser, Haidai Hu, Reinis R. Ruza, Ludovic Sauguet, Erik Lindahl, Marc Delarue
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718304844

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718304844

Similar Items