Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD

Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD

Abstract Background Whole lung tissue transcriptomic profiling studies in chronic obstructive pulmonary disease (COPD) have led to the identification of several genes associated with the severity of airflow limitation and/or the presence of emphysema, however, the cell types driving these gene expre...

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Bibliographic Details
Main Authors: Xiuying Li, Guillaume Noell, Tracy Tabib, Alyssa D. Gregory, Humberto E. Trejo Bittar, Ravi Vats, Tomasz W. Kaminski, John Sembrat, Mark E. Snyder, Divay Chandra, Kong Chen, Chunbin Zou, Yingze Zhang, Prithu Sundd, John F. McDyer, Frank Sciurba, Mauricio Rojas, Robert Lafyatis, Steve D. Shapiro, Rosa Faner, Toru Nyunoya
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Respiratory Research
Subjects:
Single cell RNA-seq
COPD
Cigarette smoke
Online Access:https://doi.org/10.1186/s12931-021-01675-2

Internet

https://doi.org/10.1186/s12931-021-01675-2

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