Curcumin Exerts Effects on the Pathophysiology of Alzheimer’s Disease by Regulating PI(3,5)P2 and Transient Receptor Potential Mucolipin-1 Expression

Curcumin Exerts Effects on the Pathophysiology of Alzheimer’s Disease by Regulating PI(3,5)P2 and Transient Receptor Potential Mucolipin-1 Expression

BackgroundTo validate our speculation that curcumin may ameliorate Alzheimer’s disease (AD) pathogenesis by regulating PI(3,5)P2 and transient receptor potential mucolipin-1 (TRPML1) expression levels.MethodsWe developed an animal model presenting AD by APP/PS1 transgenes. The mouse clonal hippocamp...

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Bibliographic Details
Main Authors: Lu Zhang, Yu Fang, Xuan Cheng, Ya-Jun Lian, Hong-liang Xu, Zhao-Shu Zeng, Hong-can Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Neurology
Subjects:
curcumin
alzheimer’s disease
Pi(3,5)P2
transient receptor potential mucolipin-1
Aβ1-42
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2017.00531/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2017.00531/full

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