Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target

Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target

The primary effector of cGMP signaling in Plasmodium is the cGMP-dependent protein kinase (PKG). Work in human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei has provided biological validation of P. falciparum PKG (PfPKG) as a drug target for treating and/or protecting again...

Full description

Bibliographic Details
Main Authors: David Rotella, John Siekierka, Purnima Bhanot
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Microbiology
Subjects:
Plasmodium
malaria
cGMP signaling
second messenger
kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.610408/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.610408/full

Similar Items