Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered Mesenchymal Stromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice

Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered Mesenchymal Stromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice

This study aimed to investigate whether the transplantation of genetically engineered bone marrow-derived mesenchymal stromal cells (MSCs) to overexpress brain-derived neurotrophic factor (BDNF) could rescue the chronic degenerative process of slow retinal degeneration in the rd6 (retinal degenerati...

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Bibliographic Details
Main Authors: Renata Lejkowska, Miłosz Piotr Kawa, Ewa Pius-Sadowska, Dorota Rogińska, Karolina Łuczkowska, Bogusław Machaliński, Anna Machalińska
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
MSC
BDNF
rd6
retinal degeneration
regenerative medicine
tissue imaging
OCT
lentiviral vectors
Online Access:https://www.mdpi.com/1422-0067/20/3/777

Internet

https://www.mdpi.com/1422-0067/20/3/777

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