Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients

Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients

Abstract This study addressed the hypothesis that epoxyeicosatrienoic acids (EETs) synthesized by CYP450 and catabolized by soluble epoxide hydrolase (sEH) are involved in the maintenance of renal allograft function, either directly or through modulation of cardiovascular function. The impact of sin...

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Bibliographic Details
Main Authors: Thomas Duflot, Charlotte Laurent, Anne Soudey, Xavier Fonrose, Mouad Hamzaoui, Michèle Iacob, Dominique Bertrand, Julie Favre, Isabelle Etienne, Clothilde Roche, David Coquerel, Maëlle Le Besnerais, Safa Louhichi, Tracy Tarlet, Dongyang Li, Valéry Brunel, Christophe Morisseau, Vincent Richard, Robinson Joannidès, Françoise Stanke-Labesque, Fabien Lamoureux, Dominique Guerrot, Jérémy Bellien
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83274-1

Internet

https://doi.org/10.1038/s41598-021-83274-1

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