Induction of Fc-Mediated Effector Functions Against a Stabilized Inner Domain of HIV-1 gp120 Designed to Selectively Harbor the A32 Epitope Region

Induction of Fc-Mediated Effector Functions Against a Stabilized Inner Domain of HIV-1 gp120 Designed to Selectively Harbor the A32 Epitope Region

Recent clinical trials and studies using nonhuman primates (NHPs) suggest that antibody-mediated protection against HIV-1 will require α-HIV envelope humoral immunity beyond direct neutralization to include Fc-receptor (FcR) mediated effector functions such as antibody-dependent cellular cytotoxicit...

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Bibliographic Details
Main Authors: Maria L. Visciano, Neelakshi Gohain, Rebekah Sherburn, Chiara Orlandi, Robin Flinko, Amir Dashti, George K. Lewis, William D. Tolbert, Marzena Pazgier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
HIV envelope
ID (Inner domain) immunogen
ADCC (Antibody dependent cellular cytotoxicity)
A32 epitope
Fc-mediated effector function
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00677/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00677/full

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