Independent Validation of an In Silico Tool for a Pilot-Scale Pharmaceutical Crystallization Process Development

Independent Validation of an In Silico Tool for a Pilot-Scale Pharmaceutical Crystallization Process Development

There are many published models for predicting crystal size distribution (CSD) in the literature. However, none of them have been independently and comprehensively tested, which is important for industrial acceptance and confidence of these models. Therefore, in this study, using solubility and kine...

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Bibliographic Details
Main Authors: Merve Öner, Francis Tran, Gitte Holm Jensen, Tim Ståhlberg, Kirsten Bisgaard-Frantzen, Stuart Michael Stocks, Jens Abildskov, Gürkan Sin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Processes
Subjects:
pharmaceutical crystallization
validation
scale-up
uncertainty and sensitivity analysis
in silico modeling
pilot-scale
Online Access:https://www.mdpi.com/2227-9717/9/4/640

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https://www.mdpi.com/2227-9717/9/4/640

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