Artificial strain of human prions created in vitro

Artificial strain of human prions created in vitro

Synthetic prions have previously been generated from recombinant rodent PrP. Here the authors generate synthetic human prions, by seeding human PrP with CJD prions, and characterize its infectivity in mice.

Bibliographic Details
Main Authors: Chae Kim, Xiangzhu Xiao, Shugui Chen, Tracy Haldiman, Vitautas Smirnovas, Diane Kofskey, Miriam Warren, Krystyna Surewicz, Nicholas R. Maurer, Qingzhong Kong, Witold Surewicz, Jiri G. Safar
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04584-z
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spelling doaj-bde375ffd18941009f755ddc28b0cf332021-05-11T10:01:41ZengNature Publishing GroupNature Communications2041-17232018-06-019111110.1038/s41467-018-04584-zArtificial strain of human prions created in vitroChae Kim0Xiangzhu Xiao1Shugui Chen2Tracy Haldiman3Vitautas Smirnovas4Diane Kofskey5Miriam Warren6Krystyna Surewicz7Nicholas R. Maurer8Qingzhong Kong9Witold Surewicz10Jiri G. Safar11Department of Pathology, Case Western Reserve UniversityDepartments of Physiology and Biophysics, Case Western Reserve UniversityDepartments of Physiology and Biophysics, Case Western Reserve UniversityDepartment of Pathology, Case Western Reserve UniversityDepartments of Physiology and Biophysics, Case Western Reserve UniversityDepartment of Pathology, Case Western Reserve UniversityDepartment of Pathology, Case Western Reserve UniversityDepartments of Physiology and Biophysics, Case Western Reserve UniversityDepartment of Pathology, Case Western Reserve UniversityDepartment of Pathology, Case Western Reserve UniversityDepartment of Pathology, Case Western Reserve UniversityDepartment of Pathology, Case Western Reserve UniversitySynthetic prions have previously been generated from recombinant rodent PrP. Here the authors generate synthetic human prions, by seeding human PrP with CJD prions, and characterize its infectivity in mice.https://doi.org/10.1038/s41467-018-04584-z
collection DOAJ
language English
format Article
sources DOAJ
author Chae Kim
Xiangzhu Xiao
Shugui Chen
Tracy Haldiman
Vitautas Smirnovas
Diane Kofskey
Miriam Warren
Krystyna Surewicz
Nicholas R. Maurer
Qingzhong Kong
Witold Surewicz
Jiri G. Safar
spellingShingle Chae Kim
Xiangzhu Xiao
Shugui Chen
Tracy Haldiman
Vitautas Smirnovas
Diane Kofskey
Miriam Warren
Krystyna Surewicz
Nicholas R. Maurer
Qingzhong Kong
Witold Surewicz
Jiri G. Safar
Artificial strain of human prions created in vitro
Nature Communications
author_facet Chae Kim
Xiangzhu Xiao
Shugui Chen
Tracy Haldiman
Vitautas Smirnovas
Diane Kofskey
Miriam Warren
Krystyna Surewicz
Nicholas R. Maurer
Qingzhong Kong
Witold Surewicz
Jiri G. Safar
author_sort Chae Kim
title Artificial strain of human prions created in vitro
title_short Artificial strain of human prions created in vitro
title_full Artificial strain of human prions created in vitro
title_fullStr Artificial strain of human prions created in vitro
title_full_unstemmed Artificial strain of human prions created in vitro
title_sort artificial strain of human prions created in vitro
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-06-01
description Synthetic prions have previously been generated from recombinant rodent PrP. Here the authors generate synthetic human prions, by seeding human PrP with CJD prions, and characterize its infectivity in mice.
url https://doi.org/10.1038/s41467-018-04584-z
work_keys_str_mv AT chaekim artificialstrainofhumanprionscreatedinvitro
AT xiangzhuxiao artificialstrainofhumanprionscreatedinvitro
AT shuguichen artificialstrainofhumanprionscreatedinvitro
AT tracyhaldiman artificialstrainofhumanprionscreatedinvitro
AT vitautassmirnovas artificialstrainofhumanprionscreatedinvitro
AT dianekofskey artificialstrainofhumanprionscreatedinvitro
AT miriamwarren artificialstrainofhumanprionscreatedinvitro
AT krystynasurewicz artificialstrainofhumanprionscreatedinvitro
AT nicholasrmaurer artificialstrainofhumanprionscreatedinvitro
AT qingzhongkong artificialstrainofhumanprionscreatedinvitro
AT witoldsurewicz artificialstrainofhumanprionscreatedinvitro
AT jirigsafar artificialstrainofhumanprionscreatedinvitro
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