Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate.

by Chae Kim, Tracy Haldiman, Yvonne Cohen, Wei Chen, Janis Blevins, Man-Sun Sy, Mark Cohen, Jiri G Safar
Published 2011-09-01

Structurally distinct external solvent-exposed domains drive replication of major human prions.

by Mohammad Khursheed Siddiqi, Chae Kim, Tracy Haldiman, Miroslava Kacirova, Benlian Wang, Jen Bohon, Mark R Chance, Janna Kiselar, Jiri G Safar
Published 2021-06-01

Structural determinants of phenotypic diversity and replication rate of human prions.

by Jiri G Safar, Xiangzhu Xiao, Mohammad E Kabir, Shugui Chen, Chae Kim, Tracy Haldiman, Yvonne Cohen, Wei Chen, Mark L Cohen, Witold K Surewicz
Published 2015-04-01

Artificial strain of human prions created in vitro

by Chae Kim, Xiangzhu Xiao, Shugui Chen, Tracy Haldiman, Vitautas Smirnovas, Diane Kofskey, Miriam Warren, Krystyna Surewicz, Nicholas R. Maurer, Qingzhong Kong, Witold Surewicz, Jiri G. Safar
Published 2018-06-01

Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

by Chae Kim, Tracy Haldiman, Krystyna Surewicz, Yvonne Cohen, Wei Chen, Janis Blevins, Man-Sun Sy, Mark Cohen, Qingzhong Kong, Glenn C Telling, Witold K Surewicz, Jiri G Safar
Published 2012-01-01