Cryo-EM structure of amyloid fibrils formed by the entire low complexity domain of TDP-43

by Qiuye Li, W. Michael Babinchak, Witold K. Surewicz
Published 2021-03-01

Small molecules as potent biphasic modulators of protein liquid-liquid phase separation

by W. Michael Babinchak, Benjamin K. Dumm, Sarah Venus, Solomiia Boyko, Andrea A. Putnam, Eckhard Jankowsky, Witold K. Surewicz
Published 2020-11-01

Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome

by Jonah J. Scott-McKean, Adriano L. Roque, Krystyna Surewicz, Mark W. Johnson, Witold K. Surewicz, Alberto C. S. Costa
Published 2018-01-01

Species-dependent structural polymorphism of Y145Stop prion protein amyloid revealed by solid-state NMR spectroscopy

by Theint Theint, Philippe S. Nadaud, Darryl Aucoin, Jonathan J. Helmus, Simon P. Pondaven, Krystyna Surewicz, Witold K. Surewicz, Christopher P. Jaroniec
Published 2017-09-01

Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments

by Laura Cracco, Xiangzhu Xiao, Satish K. Nemani, Jody Lavrich, Ignazio Cali, Bernardino Ghetti, Silvio Notari, Witold K. Surewicz, Pierluigi Gambetti
Published 2019-05-01

Antimicrobial activity of human prion protein is mediated by its N-terminal region.

by Mukesh Pasupuleti, Markus Roupe, Victoria Rydengård, Krystyna Surewicz, Witold K Surewicz, Anna Chalupka, Martin Malmsten, Ole E Sörensen, Artur Schmidtchen
Published 2009-01-01

Structural determinants of phenotypic diversity and replication rate of human prions.

by Jiri G Safar, Xiangzhu Xiao, Mohammad E Kabir, Shugui Chen, Chae Kim, Tracy Haldiman, Yvonne Cohen, Wei Chen, Mark L Cohen, Witold K Surewicz
Published 2015-04-01

Soluble prion protein and its N-terminal fragment prevent impairment of synaptic plasticity by Aβ oligomers: Implications for novel therapeutic strategy in Alzheimer's disease

by Jonah J. Scott-McKean, Krystyna Surewicz, Jin-Kyu Choi, Vernon A. Ruffin, Ahlam I. Salameh, Krzysztof Nieznanski, Alberto C.S. Costa, Witold K. Surewicz
Published 2016-07-01

Enhanced neuroinvasion by smaller, soluble prions

by Cyrus Bett, Jessica Lawrence, Timothy D. Kurt, Christina Orru, Patricia Aguilar-Calvo, Anthony E. Kincaid, Witold K. Surewicz, Byron Caughey, Chengbiao Wu, Christina J. Sigurdson
Published 2017-04-01

Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

by Chae Kim, Tracy Haldiman, Krystyna Surewicz, Yvonne Cohen, Wei Chen, Janis Blevins, Man-Sun Sy, Mark Cohen, Qingzhong Kong, Glenn C Telling, Witold K Surewicz, Jiri G Safar
Published 2012-01-01

Thermodynamic Stabilization of the Folded Domain of Prion Protein Inhibits Prion Infection in Vivo

by Qingzhong Kong, Jeffrey L. Mills, Bishwajit Kundu, Xinyi Li, Liuting Qing, Krystyna Surewicz, Ignazio Cali, Shenghai Huang, Mengjie Zheng, Wieslaw Swietnicki, Frank D. Sönnichsen, Pierluigi Gambetti, Witold K. Surewicz
Published 2013-07-01

A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease

by Satish K. Nemani, Xiangzhu Xiao, Ignazio Cali, Laura Cracco, Gianfranco Puoti, Massimiliano Nigro, Jody Lavrich, Anuradha Bharara Singh, Brian S. Appleby, Valerie L. Sim, Silvio Notari, Witold K. Surewicz, Pierluigi Gambetti
Published 2020-06-01

Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors

by Romany Abskharon, Johnny Dang, Ameer Elfarash, Zerui Wang, Pingping Shen, Lewis S. Zou, Sedky Hassan, Fei Wang, Hisashi Fujioka, Jan Steyaert, Mentor Mulaj, Witold K. Surewicz, Joaquín Castilla, Alexandre Wohlkonig, Wen-Quan Zou
Published 2017-10-01

Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity.

by Fei Wang, Xinhe Wang, Christina D Orrú, Bradley R Groveman, Krystyna Surewicz, Romany Abskharon, Morikazu Imamura, Takashi Yokoyama, Yong-Sun Kim, Kayla J Vander Stel, Kumar Sinniah, Suzette A Priola, Witold K Surewicz, Byron Caughey, Jiyan Ma
Published 2017-07-01