Altered Ca2+ and Na+ Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis

Altered Ca2+ and Na+ Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis

Hypertrophic cardiomyopathy (HCM) is the most common mendelian heart disease, with a prevalence of 1/500. HCM is a primary cause of sudden death, due to an heightened risk of ventricular tachyarrhythmias that often occur in young asymptomatic patients. HCM can slowly progress toward heart failure, e...

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Bibliographic Details
Main Authors: Raffaele Coppini, Cecilia Ferrantini, Alessandro Mugelli, Corrado Poggesi, Elisabetta Cerbai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
cardiac hypertrophy
ion channels
ranolazine
arrhythmias
afterdepolarization
calmodulin kinase (CaMKII)
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01391/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01391/full

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